Center «Laser optical technoligies for medicine and biology»

Head of the Center: Vitaly Plavsky, PhD, Deputy Director

Main areas of research:

laser physics (distributed feedback laser emitters based on thin films doped with dyes and nanoparticles)
study of physicochemical processes in organic systems by kinetic laser spectroscopy;
laser-optical technologies for monitoring gas exchange processes in biological tissues.
The most important results:

original polarization methods were developed for measuring the kinetics of ultrafast spectroscopic processes, which made it possible to investigate the kinetics of the formation and rupture of intermolecular hydrogen bonds in solutions and to determine the influence of these processes on their spectroscopic properties;
the physical foundations of the theory of fluctuation microinhomogeneities in solutions of organic compounds were created and their manifestations in the absorption and emission spectra were studied. Inhomogeneous broadening of the spectra of dye molecules in solutions was found;
A new method for spectral investigation of heterogeneous systems is proposed — spectroscopy of red edge excitation; on this basis, an approach to the study of biological membranes has been developed, which made it possible to obtain information about the spatial distribution of the microparameters of the membrane along its depth;
theoretically analyzed and experimentally investigated the influence of interference laser fields on microparticles of various nature in a liquid; the possibility of using such fields to control the microstructure of heterogeneous media and influence the course of processes in biological objects is shown;
lasers based on both dynamic and stationary DFB with high temperature stability of the generation wavelength were developed;
Experimental in vitro study of the dependence of the efficiency of carboxyhemoglobin deactivation in human blood when exposed to laser radiation of different wavelengths. A method is proposed for photodegradation of carboxyhemoglobin in the blood, which reduces the time taken to remove the poisonous effect of carbon monoxide by an order of magnitude compared to the traditional method of hyperventilation of the lungs with pure oxygen;
The fluorescent characteristics of healthy and cancerous human thyroid tissue samples were investigated. It is established that the average lifetime of fluorescence in samples of healthy thyroid tissue is significantly less than in samples of cancer tissue. The results can be used in the creation of optical devices for the diagnosis of cancer in the tissues of the human thyroid gland.